Retatrutide (Triple Agonist)

Product Overview Retatrutide is a synthetic unimolecular peptide and a potent triple agonist targeting the glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and glucagon (GCG) receptors. This multi-receptor activation profile represents a significant evolution in the study of incretin mimetics and metabolic regulation. By simultaneously engaging three distinct pathways, Retatrutide allows researchers to evaluate the synergistic effects of insulinotropism, glucagon-mediated thermogenesis, and satiety signaling in various animal and cellular models.

Product Specifications

• Purity: >99% (HPLC verified)

• Format: Lyophilized White Powder

• Storage: Store at -20°C (-4°F) for long-term stability. Protect from light.

Key Research Areas

• Triple Receptor Synergy: Investigating the combined impact of GLP-1R, GIPR, and GCGR activation on glucose homeostasis and energy expenditure.

• Metabolic Rate & Thermogenesis: Researching the glucagon receptor's role in stimulating energy expenditure and lipid oxidation.

• Appetite Regulation: Evaluating the central and peripheral mechanisms of satiety and delayed gastric emptying in obesity research models.

• Insulin Sensitivity: Assessing the peptide’s influence on pancreatic beta-cell function and systemic insulin response.

   

Handling & Reconstitution For laboratory evaluation, reconstitute with Bacteriostatic Water (BAC). Due to its complex peptide structure, avoid vigorous agitation during reconstitution. Once reconstituted, store at 2–8°C (36–46°F) and utilize within the recommended experimental window to maintain structural integrity.