Semaglutide

Semaglutide (GLP-1 Receptor Agonist)

Product Overview

Semaglutide is a long-acting synthetic analog of the endogenous incretin hormone, glucagon-like peptide-1 (GLP-1). It is engineered with a 94% sequence homology to human GLP-1, featuring two key structural modifications: the substitution of alanine with alpha-aminoisobutyric acid at position 8 (enhancing resistance to DPP-4 enzymatic degradation) and the attachment of a C18 fatty diacid chain via a spacer at position 26. These modifications allow for high-affinity binding to albumin, resulting in a significantly extended half-life and sustained activation of the GLP-1 receptor (GLP-1R) in research models.

Product Specifications

• Purity: >99% (HPLC verified)

• Format: Lyophilized White Powder

• Storage: Store at -20°C (-4°F) for long-term stability. Protect from light.

Key Research Areas

• Incretin Mimicry: Investigation of the peptide's ability to stimulate glucose-dependent insulin secretion from pancreatic beta cells.

• Glycemic Regulation: Researching the suppression of inappropriate glucagon secretion and the stabilization of postprandial glucose levels.

• Gastric Dynamics: Evaluating the influence of GLP-1R activation on the rate of gastric emptying and nutrient absorption.

• Neuro-Metabolic Signaling: Assessing the central nervous system pathways involved in satiety signaling and appetite regulation within the hypothalamus.

Handling & Reconstitution

For laboratory evaluation, reconstitute with Bacteriostatic Water (BAC). To preserve the integrity of the fatty acid side chain, allow the diluent to flow gently down the side of the vial and avoid vigorous shaking. Once reconstituted, store at 2–8°C (36–46°F) and utilize within the recommended experimental timeframe.